Serdecznie zapraszam na kolejny wykład z cyklu AMU Invited Lecture Series in Functional Nanomaterials , który odbędzie się w środę, 22 marca br. o godz. 11.00, na platformie TEAMS.
Wykład pt. "Chirality matters: supramolecular systems from heterochiral short peptides” wygłosi Prof. Silvia Marchesan, University of Trieste, Italy (https://www.marchesanlab.com).
Link do spotkania:
Nature’s choice for homochirality has stimulated our research, as we question it with heterochirality. The scientific journey in this direction starts from the design of short peptides to define self-assembly rules within chemical systems of biological relevance. We use one or two D-amino acids in D,L-tripeptides and study small libraries with variations in stereochemistry or amino acid sequence. We established how chirality affects spatial conformation for assembly from the molecular, nano-, micro- and through to the macro-scale, to link the macroscopic properties back to structural details of the building blocks. As an example, substitution of intermolecular with intramolecular interactions can be used to direct self-organization and impede the uncontrolled formation of hierarchical structures. As Alice steps beyond the mirror and enters Wonderland, we can get inspired by D-amino acids and use them in D,L-peptides to achieve functional superstructures. We monitored molecular conformation and its evolution as a continuum to macroscopic hydrogels. We have now identified a more diverse library of self-assembling tripeptides with different functional groups. Applications range from (antimicrobial) biomaterial to supramolecular catalysis, amyloid inhibition, and molecular separation in combination with orthogonal supramolecular systems, with a function that can be switched on/off with assembly/disassembly.
Serdecznie zapraszam do uczestnictwa w wykładzie.