prof. Christine Mezard, wtorek 23 maja, godz. 10:00 Sala Rady Wydziału na Wydziale Biologii

Informacja o wykładowcy i wykładzie:

Professor Christine Mézard has been working at the Jean-Pierre Bourgin Institute at INRAE since 2001, which is part of the University of Paris-Saclay, where she holds an independent position in the Meiosis Mechanisms group. Her main research interests concern the characterization of the distribution of meiotic Crossover (CO) in the plant Arabidopsis thaliana. She was the first who demonstrated that COs are not evenly distributed along the chromosomes. Moreover, Christine's group produced the first genetic map of female meiosis and showed that there was heterochiasmy in Arabidopsis thaliana with a lower CO rate and a different CO distribution in female meiosis compared to male meiosis. Within the male genetic map, she observed that COs tend to cluster in small regions of a few kilobases revealing the existence of Hotspots of meiotic recombination as described in mice, humans and S. cerevisiae. Later, she set up a “pollen typing” technique to characterize these hotspots and demonstrated that they behave like the one described in other species containing not only crossover but also non-crossover events. More recently, Christine studied the relationships between DNA methylation and CO distribution and showed that in a mutant that impairs the neddylation pathway, DNA methylation and CO localization are uncoupled. In her talk Christine will present her most recent, mostly unpublished work on identification of new components of meiotic chromosomes which affects both chromosome structure and crossover formation.